7-Amino-3-cephem-4-acidi carboxylic
Basic Information:
Anglicus alias:
7-ANCA;7-AMOCA;(6R,7R)-7-AMino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicAcid;7-NACA;7- NACA.7-ANCA;7-ANCAChemicalbookimpurity;CeftizoximeImpurity9;CeftizoximeImpurity16;Ceftizoximeintermediate(7-anca);7-amino-3-cephem-4-carboxylicacid
CAS number: 36923-178
Formulae hypotheticae: C7H8N2O3S
Pondus hypotheticum: 200.21
EINECS number: 609-312-7
Formulae structurae:
Genera affinia: media organica; Intermedia pharmaceutica; Materia pharmaceutica rudis.
Punctum liquescens: 215-218°C
Fervens punctum: 536.9±50.0 °C (Predictum)
Densitas: 1.69± 0.1g /cm3(Praedicta)
Index refractivus: 1.735 (aestimatio)
Flash point: 278.508°C
Solubilitas: Solubilis in solutione aquea acidica (levis, calefacta), DMSO (levi). Proprietates: Album seu album crystallinum pulveris.
Vapor pressus: 0mmHg in 25°C
| specificatio | unitas | vexillum |
| Aspectus | Album aut album crystallinum pulveris | |
| Summa content | % | ≥98.5% |
| umor | % | ≤1 |
| Mono hybrid | % | ≤0.5 |
| Totalis clutter | % | ≤1 |
Cephalosporin, in medio cefbutan et cefazoxime.
Acidum sulphuricum attenti (104.3mL, 1.92mol) adiectum est in tres utres, deinde acidum isophthalicum (40g, 0.24mol) adiectum, incitatum et calefactum ad 60℃, pro 0.5h, et 60% acidum nitricum (37.8g, 0.36; mol) addita est ad moderandum gradum accelerationis guttae. Adde in 2 horis. Post additionem, calor conservationis reactionem in 60℃ pro 2 horis. Refrigescant ut infra L° C, deinde 100mL aquae add. Materia refrigerata est ad cella temperiem, in colum infunditur, exantlaretur ad removendum acidum vastum, placenta colum lota aqua, exhausta ad recrystallize, et productum album 34.6 P., cessus erat 68.4%.
20Kg vel 25Kg/ situla, situla cardboard, strato albo et sacco polyethylene nigro instruxit. 2℃-8℃ siccum, refrigerium, a repositione levi, valida per 2 annos.
